Linkage between Cryptorchidism, Hypospadias, and GGN Repeat Length in the Androgen Receptor Gene

association of androgen receptor ggn repeat length polymorphism and male infertility in khuzestan, iran

background: androgens play critical role in secondary sexual and male gonads differentiations such as spermatogenesis, via androgen receptor. the human androgen receptor (ar) encoding gene contains two regions with three nucleotide polymorphic repeats (cag and ggn) in the first exon. unlike the cag repeats, the ggn has been less studied because of technical difficulties, so the functional role ...

Hypospadias and the androgen receptor gene: mutation screening and CAG repeat length analysis.

We report on mutation screening and CAG repeat length analysis of the androgen receptor (AR) gene in 21 patients with hypospadias. The urethral meatus was located at the glandular region in six patients (glandular type), at the penile shaft in seven patients (penile type), and at the scrotal/perineal region in eight patients (scrotal/perineal type). Mutation screening was performed for exons 1-...

Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we conducted two case-control studies in a Chinese population to investigate the possible relationship ...

Retraction: Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

Assessment of Correlation between Androgen Receptor CAG Repeat Length and Infertility in Infertile Men Living in Khuzestan, Iran

Background The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. MaterialsAndMethods In this case-control study during two years till 20...